MacIntyre D, Boyd G
Clin Allergy. 1983 May;13(3):213-8. doi: 10.1111/j.1365-2222.1983.tb02590.x.
The density dependence of maximum flow in ten atopic asthmatics was assessed by response to breathing a helium-oxygen mixture. They were then subjected to bronchial challenge by Dermatophagoides pteronyssinus and density dependence re-assessed during early and late bronchial reactions. There was considerable individual variation in the density dependence before challenge and in the change in density dependence during induced bronchospasm. However, for any given individual the results were similar during early and late reactions. This suggests that the major site of airflow obstruction may vary from one asthmatic to another but that when antigen challenge is followed by a dual early and late reaction the site of obstruction is similar at each stage.
通过对10名特应性哮喘患者吸入氦氧混合气体的反应来评估最大流量的密度依赖性。然后，他们接受了粉尘螨的支气管激发试验，并在支气管反应的早期和晚期重新评估密度依赖性。激发试验前的密度依赖性以及诱导支气管痉挛期间密度依赖性的变化存在相当大的个体差异。然而，对于任何给定个体，早期和晚期反应的结果相似。这表明气流阻塞的主要部位可能因哮喘患者而异，但当抗原激发引发早期和晚期双重反应时，每个阶段的阻塞部位相似。
