Veith R C, Raskind M A, Barnes R F, Gumbrecht G, Ritchie J L, Halter J B
Clin Pharmacol Ther. 1983 Jun;33(6):763-9. doi: 10.1038/clpt.1983.104.
Fourteen depressed patients were treated for 1 to 8 wk (4.1 +/- 0.6, mean +/- SEM) with imipramine, doxepin, or amitriptyline to study the effects of tricyclic antidepressants (TCAs) on sympathetic nervous system (SNS) function. Eight had chronic but medically stable cardiac disease and six were medically healthy. Supine plasma norepinephrine (NE) and epinephrine (EPI) levels, mean arterial blood pressure (MAP), and heart rate were measured at rest, after standing, and during graded, supine maximal bicycle exercise. Eight nondepressed patients with cardiac disease were studied without drug intervention as controls. There were no baseline differences in any of these measures among the medically healthy depressed subjects, the depressed cardiac patients, and the eight nondepressed patients matched for cardiac disease. After TCAs, NE was increased by 51 +/- 6% of basal values and heart rate rose, but EPI and MAP were unchanged. The supine to 10-min standing increment in NE increased from 309 +/- 51 pg/ml at baseline to 406 +/- 55 pg/ml during TCA treatment. These findings are compatible with an increase in SNS outflow after TCAs.
14名抑郁症患者接受了1至8周（4.1±0.6，平均值±标准误）的丙咪嗪、多塞平或阿米替林治疗，以研究三环类抗抑郁药（TCA）对交感神经系统（SNS）功能的影响。其中8人患有慢性但病情稳定的心脏病，6人身体健康。在静息状态、站立后以及仰卧位分级最大强度自行车运动期间，测量了仰卧位血浆去甲肾上腺素（NE）和肾上腺素（EPI）水平、平均动脉血压（MAP）以及心率。8名患有心脏病的非抑郁症患者作为对照，在未进行药物干预的情况下接受了研究。在身体健康的抑郁症患者、患有心脏病的抑郁症患者以及8名与心脏病匹配的非抑郁症患者之间，这些测量指标在基线时均无差异。使用TCA治疗后，NE升高至基础值的51±6%，心率上升，但EPI和MAP未发生变化。NE从基线时仰卧位到站立10分钟时的增加值从309±51 pg/ml增加至TCA治疗期间的406±55 pg/ml。这些发现与TCA治疗后SNS传出增加相一致。
