Ross R J, Scheinin M, Lesieur P, Rudorfer M V, Hauger R L, Siever L J, Linnoila M, Potter W Z
Psychopharmacology (Berl). 1985;85(2):227-30. doi: 10.1007/BF00428420.
A low dosage of the specific MAO-A inhibitor clorgyline (5-10 mg/day) was administered chronically to 10 depressed patients. Peripheral noradrenergic activity, as assessed by measurements of the plasma norepinephrine (NE) concentration, heart rate, and blood pressure, was determined before and after drug treatment. The administration of a low dosage of clorgyline was associated with a decrement in peripheral presynaptic noradrenergic activity. Comparison with the results of similar studies of the effects of desmethylimipramine (DMI) suggests that antidepressant drugs with unrelated primary actions affect peripheral noradrenergic functions differently.
对10名抑郁症患者长期给予低剂量的特定单胺氧化酶A抑制剂氯吉兰（5 - 10毫克/天）。在药物治疗前后，通过测量血浆去甲肾上腺素（NE）浓度、心率和血压来评估外周去甲肾上腺素能活性。给予低剂量氯吉兰与外周突触前去甲肾上腺素能活性降低有关。与去甲丙咪嗪（DMI）作用效果的类似研究结果相比，表明具有不同主要作用的抗抑郁药物对外周去甲肾上腺素能功能的影响不同。
