Ho P C, Liang S T, Tang G W, Ma H K
Contraception. 1983 Apr;27(4):339-46. doi: 10.1016/s0010-7824(83)80014-6.
The effect of a prostaglandin E1 analogue on the cervix prior to termination of first trimester pregnancy was studied in a double-blind placebo-controlled trial with 70 primigravid and 125 multigravid patients in the Hong Kong University Gynaecological Unit. One mg of 16, 16-dimethyl-trans-delta 2-prostaglandin E1 methyl ester (ONO 802) in the form of vaginal pessary was inserted 3 hours before vacuum aspiration. The cervical dilatation in patients receiving ONO 802 pessaries was significantly greater than that in patients who received no treatment or placebo pessaries but the difference in dilatation between patients who received no treatment or placebo was not significant. The blood loss during operation in patients receiving ONO 802 pessaries was also significantly less than that in patients receiving placebo pessaries. The side effects due to ONO 802 pessaries were mild and infrequent.
香港大学妇科病房对70名初产妇和125名经产妇进行了一项双盲安慰剂对照试验，研究一种前列腺素E1类似物在妊娠早期终止前对宫颈的作用。在真空吸引前3小时，以阴道栓剂的形式插入1毫克16,16 - 二甲基 - 反式 - δ2 - 前列腺素E1甲酯（ONO 802）。接受ONO 802栓剂的患者宫颈扩张明显大于未接受治疗或接受安慰剂栓剂的患者，但未接受治疗或接受安慰剂的患者之间的扩张差异不显著。接受ONO 802栓剂的患者手术期间的失血量也明显少于接受安慰剂栓剂的患者。ONO 802栓剂引起的副作用轻微且不常见。
