DeVore D P, Hughes E, Scott J B
Autogenesis Technologies Inc., Acton, MA 01720.
Med Prog Technol. 1994;20(3-4):243-50.
Both synthetic and biological materials have been used for smoothing wrinkle lines and depressed scars. Injectable fillers provide a convenient and easy alternative to surgical methods to treat dermal defects. Optimally, injectable fillers augmenting dermal tissue should exhibit properties similar to the dermal collagen network, providing a stable matrix for long-term correction but also being subject to the dynamic changes that occur to dermal tissue during the aging processes. At present, only biological materials are available on a commercial basis, although a number of synthetic injectables are being evaluated in clinical trials. The long-term effectiveness of most commercial materials has been limited prompting questions about the cost-benefits of such treatment. In this regard, the effectiveness of the injectable fillers, particularly of biological materials, will be discussed as will the difficulties involved in determining the expected result (effectiveness) for specific materials and in providing methods of measuring effectiveness.
合成材料和生物材料都已被用于抚平皱纹和凹陷性瘢痕。可注射填充剂为治疗皮肤缺陷的手术方法提供了一种方便易行的替代方案。理想情况下，增强真皮组织的可注射填充剂应具有与真皮胶原网络相似的特性，既能为长期矫正提供稳定的基质，又能适应衰老过程中真皮组织发生的动态变化。目前，虽然有一些合成可注射材料正在临床试验中进行评估，但只有生物材料在商业上可用。大多数商业材料的长期有效性有限，这引发了对此类治疗成本效益的质疑。在这方面，将讨论可注射填充剂的有效性，特别是生物材料的有效性，以及确定特定材料预期效果（有效性）和提供有效性测量方法所涉及的困难。
