Kar R N, Das R K
Cytobios. 1983;36(142):73-82.
Chromosomal preparations were examined for structural and numerical abnormalities induced by chlordiazepoxide (CDZ) in mice which received either a single oral dose (20 mg/kg) or multiple doses (10, 20, 40 and 80 mg/kg) for time-response and dose-response studies, respectively. The sampling was done at different post-treatment hours. The structural aberrations recorded were mostly of the chromatid type. CDZ induced a significant increase in chromosomal aberration frequencies at all sampling hours with a peak at 32 h post-treatment. In dose-response studies all the dose groups showed a significant increase over controls but the effect was maximum at the lowest dose level.
对接受单次口服剂量（20毫克/千克）或多次剂量（10、20、40和80毫克/千克）的小鼠进行染色体制备检查，分别用于时间反应和剂量反应研究，以检测氯氮卓（CDZ）诱导的结构和数量异常。在不同的治疗后时间点进行采样。记录的结构畸变大多为染色单体类型。CDZ在所有采样时间点均导致染色体畸变频率显著增加，在治疗后32小时达到峰值。在剂量反应研究中，所有剂量组与对照组相比均显示出显著增加，但在最低剂量水平时效应最大。
