Matsui K, Share L, Wang B C, Crofton J T, Brooks D P
Endocrinology. 1983 Jun;112(6):2107-13. doi: 10.1210/endo-112-6-2107.
A study was made of the effects of changes in the plasma vasopressin concentration on the extraction ratio and the renal organ and urinary clearances of vasopressin. Plasma vasopressin levels were increased in a stepwise fashion in anesthetized dogs by the iv infusion of vasopressin at rates of 100, 400, and 800 microU/min . kg. A steady state was achieved by infusing vasopressin for 60 min at each dose. Before the infusion of vasopressin, the extraction ratio and the renal and urinary clearances of vasopressin (one kidney) were 0.30 +/- 0.04, 1.8 +/- 0.2, and 1.4 +/- 0.1 ml/min . kg, respectively. The urinary clearance of vasopressin did not differ significantly from the inulin clearance (1.5 +/- 0.1 ml/min . kg). The infusion of vasopressin, which increased the plasma vasopressin concentration from an initial value of 4.3 +/- 1.3 to 54.6 +/- 2.4 microU/ml at the highest rate of infusion, was without effect on the vasopressin extraction ratio and the renal and urinary clearances of vasopressin. The MCR of vasopressin was estimated to be approximately 16 ml/min . kg. The renal clearance of vasopressin, calculated for both kidneys in all periods of all experiments, accounted for approximately 27% of the total clearance of vasopressin from the plasma. Thus, over a broad range of plasma vasopressin concentrations, a constant fraction of the vasopressin delivered to the kidney was removed from the blood perfusing the kidney, and the mechanisms for the renal extraction of vasopressin were not saturated.
研究了血浆血管加压素浓度变化对血管加压素提取率、肾脏器官清除率和尿清除率的影响。在麻醉犬中，通过以100、400和800微单位/分钟·千克的速率静脉输注血管加压素，使血浆血管加压素水平逐步升高。在每个剂量下输注血管加压素60分钟以达到稳态。在输注血管加压素之前，血管加压素的提取率、肾脏清除率和尿清除率（单肾）分别为0.30±0.04、1.8±0.2和1.4±0.1毫升/分钟·千克。血管加压素的尿清除率与菊粉清除率（1.5±0.1毫升/分钟·千克）无显著差异。以最高输注速率输注血管加压素，使血浆血管加压素浓度从初始值4.3±1.3升高至54.6±2.4微单位/毫升，对血管加压素的提取率以及肾脏和尿清除率均无影响。血管加压素的代谢清除率估计约为16毫升/分钟·千克。在所有实验的所有时间段内，对双肾计算的血管加压素肾脏清除率约占血浆中血管加压素总清除率的27%。因此，在广泛的血浆血管加压素浓度范围内，输送到肾脏的血管加压素中有恒定比例从灌注肾脏的血液中被清除，且肾脏提取血管加压素的机制未达到饱和。
