Share L, Kimura T, Matsui K, Shade R E, Crofton J T
Fed Proc. 1985 Jan;44(1 Pt 1):59-61.
The clearance of vasopressin (VP) by the kidneys and splanchnic viscera was studied in the anesthetized dog. VP is bound to plasma protein, 10% at basal plasma VP levels and 40% at plasma VP concentrations greater than 20 microU/ml. The urinary clearance of VP is 70-100% of the glomerular filtration rate; the renal organ clearance of the hormone is 20-30% greater than its urinary clearance. There is evidence that the renal organ clearance of VP is affected by changes in both glomerular filtration rate and renal blood flow. The renal clearance of VP is a result of glomerular filtration, degradation, or reabsorption in the proximal nephron, and secretion into the distal nephron. In the short term, the renal clearance of VP is unaffected either by changes in the plasma VP concentration over a broad range or by moderate hemorrhage. The splanchnic clearance of VP is accomplished almost equally by the intestine and the liver. Because the sum of the splanchnic and renal clearances of VP is less than estimates of its metabolic clearance rate, there may be a physiologically significant clearance of VP by organs in addition to the kidneys and splanchnic viscera.
在麻醉犬身上研究了肾脏和内脏对血管加压素（VP）的清除情况。VP与血浆蛋白结合，基础血浆VP水平时结合率为10%，血浆VP浓度大于20微单位/毫升时结合率为40%。VP的尿清除率为肾小球滤过率的70 - 100%；该激素的肾脏器官清除率比其尿清除率高20 - 30%。有证据表明，VP的肾脏器官清除率受肾小球滤过率和肾血流量变化的影响。VP的肾脏清除是肾小球滤过、近端肾单位降解或重吸收以及向远端肾单位分泌的结果。短期内，VP的肾脏清除率不受血浆VP浓度在较宽范围内变化或中度出血的影响。VP的内脏清除几乎由肠道和肝脏平均完成。由于VP的内脏和肾脏清除率之和低于其代谢清除率的估计值，除肾脏和内脏外，其他器官可能对VP有生理意义的清除作用。
