Hietanen E, Laitinen M, Ahonen E, Marniemi J, Nousiainen U
Enzyme. 1983;29(3):160-6. doi: 10.1159/000469628.
In 32 women of normal body weight who volunteered to participate in the study, the effect of rapid weight reduction by a low-calorie liquid diet on serum lipids and lecithin:cholesterol acyltransferase (LCAT) enzyme activity was studied. Women were on this 400 kJ/day diet for 7 days and fasting blood samples were drawn before and immediately after the diet. Serum cholesterol decreased from 5.7 +/- 1.0 to 5.2 +/- 1.1 mmol/l and high density lipoprotein cholesterol from 1.77 +/- 0.43 to 1.50 +/- 0.35 mmol/l. The serum LCAT activity decreased significantly during the weight reduction period. When serum LCAT activity was correlated to lipid parameters, a positive correlation was found with total cholesterol and triglyceride concentrations before weight reduction and also between changes in LCAT activity and total cholesterol concentration. The data suggest that serum LCAT activity might have a prominent role in the regulation of serum lipid levels.
在32名自愿参与该研究的体重正常的女性中，研究了低热量流质饮食快速减重对血脂及卵磷脂胆固醇酰基转移酶（LCAT）活性的影响。这些女性采用每天400千焦的饮食持续7天，并在饮食前及饮食结束后立即采集空腹血样。血清胆固醇从5.7±1.0毫摩尔/升降至5.2±1.1毫摩尔/升，高密度脂蛋白胆固醇从1.77±0.43毫摩尔/升降至1.50±0.35毫摩尔/升。在减重期间，血清LCAT活性显著降低。当血清LCAT活性与脂质参数相关联时，发现其与减重前的总胆固醇和甘油三酯浓度呈正相关，并且LCAT活性变化与总胆固醇浓度之间也呈正相关。数据表明，血清LCAT活性可能在血清脂质水平的调节中起重要作用。
