男性体内卵磷脂胆固醇酰基转移酶（LCAT）质量浓度与运动、体重减轻及血浆脂蛋白亚组分浓度的关联
Associations of lecithin: cholesterol acyltransferase (LCAT) mass concentrations with exercise, weight loss, and plasma lipoprotein subfraction concentrations in men.
作者信息
Williams P T, Albers J J, Krauss R M, Wood P D
机构信息
Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, CA.
出版信息
Atherosclerosis. 1990 May;82(1-2):53-8. doi: 10.1016/0021-9150(90)90143-7.
The relationships between plasma lecithin:cholesterol acyltransferase (LCAT) mass concentrations and lipids, apolipoprotein, and lipoprotein subfraction concentrations were studied in men assigned at random to a one-year exercise program (n = 48) and to a sedentary control condition (n = 31). Exercise training did not significantly affect mean concentrations of LCAT-mass. Moreover changes in LCAT within the exercise group were unrelated to distance run and weight loss. The baseline data and the one-year change data showed consistent positive correlations between LCAT concentrations and total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, and apolipoprotein B concentrations, and consistently weak correlations between LCAT concentrations and high density lipoprotein (HDL)-cholesterol, HDL2, and apolipoprotein A-I concentrations. The strong correlation between LCAT and total cholesterol may account for LCAT's relationships with lipoprotein subfractions, apolipoprotein B and other lipoprotein cholesterol concentrations.
在随机分配到为期一年的运动计划组（n = 48）和久坐不动的对照组（n = 31）的男性中，研究了血浆卵磷脂：胆固醇酰基转移酶（LCAT）质量浓度与脂质、载脂蛋白和脂蛋白亚组分浓度之间的关系。运动训练并未显著影响LCAT质量的平均浓度。此外，运动组内LCAT的变化与跑步距离和体重减轻无关。基线数据和一年变化数据显示，LCAT浓度与总胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇和载脂蛋白B浓度之间存在一致的正相关，而LCAT浓度与高密度脂蛋白（HDL）胆固醇、HDL2和载脂蛋白A-I浓度之间的相关性始终较弱。LCAT与总胆固醇之间的强相关性可能解释了LCAT与脂蛋白亚组分、载脂蛋白B和其他脂蛋白胆固醇浓度之间的关系。
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