皮下接种单纯疱疹病毒的大鼠中枢神经系统中的软脑膜炎和多核细胞形成
Leptomeningitis and polycaryocyte formation in the CNS of rats inoculated subcutaneously with herpes simplex virus.
作者信息
Percy D H, Galil K A, Hatch L A
出版信息
Exp Mol Pathol. 1983 Jun;38(3):398-404. doi: 10.1016/0014-4800(83)90079-5.
Wistar rats were inoculated subcutaneously with either type 1 (HSV1) or type 2 (HSV2) Herpes simplex virus at 5 days of age. Animals were killed in extremis or at the end of the 14-day observation period postinoculation. Acute destructive meningoencephalitis with hemorrhage and leukocytic infiltration was observed in both groups. Polycaryocytes comprised of cells of the internal granular layer of the cerebellum were observed in some animals inoculated with HSV1. These multinucleated cells appeared to be formed by fusion of virus-infected cells, and intranuclear inclusion bodies were observed. Lesions in the leptomeninges were particularly striking in animals inoculated with HSV2. Viral replication in resident cells of the leptomeninges was demonstrated by electron microscopy.
在5日龄时，将1型单纯疱疹病毒（HSV1）或2型单纯疱疹病毒（HSV2）皮下接种到Wistar大鼠体内。在濒死期或接种后14天观察期结束时处死动物。两组均观察到伴有出血和白细胞浸润的急性破坏性脑膜脑炎。在一些接种HSV1的动物中观察到由小脑内颗粒层细胞组成的多核细胞。这些多核细胞似乎是由病毒感染细胞融合形成的，并且观察到核内包涵体。在接种HSV2的动物中，软脑膜病变尤为明显。通过电子显微镜证实了软脑膜驻留细胞中的病毒复制。
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