大鼠快肌和慢肌发育过程中肌球蛋白转变的甲状腺和神经控制
Thyroidal and neural control of myosin transitions during development of rat fast and slow muscles.
作者信息
Gambke B, Lyons G E, Haselgrove J, Kelly A M, Rubinstein N A
出版信息
FEBS Lett. 1983 Jun 13;156(2):335-9. doi: 10.1016/0014-5793(83)80524-9.
PMID:6852266
Abstract
Experiments with developing euthyroid, hypothyroid and hyperthyroid rats show that the transition from neonatal to adult fast myosin is orchestrated by thyroid hormones acting directly upon fast muscle cells. Denervation studies reveal the switch from neonatal to adult fast myosin synthesis is independent of the motoneuron. However the synthesis of slow myosin during development is critically dependent on innervation.
摘要
对发育中的甲状腺功能正常、甲状腺功能减退和甲状腺功能亢进大鼠进行的实验表明，从新生型快速肌球蛋白向成年型快速肌球蛋白的转变是由甲状腺激素直接作用于快肌细胞来调控的。去神经支配研究表明，从新生型向成年型快速肌球蛋白合成的转变与运动神经元无关。然而，发育过程中慢肌球蛋白的合成严重依赖于神经支配。
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