先天性胸腺发育不全的rnu/rnu“裸”大鼠的免疫球蛋白
Immunoglobulins of rnu/rnu 'nude' rats with congenital aplasia of the thymus.
作者信息
Taubman M A, Ebersole J L, Smith D J
出版信息
Immunology. 1983 Jun;49(2):295-300.
Abstract
The levels of immunoglobulins (Ig) in the serum and saliva of nude (rnu/rnu) congenitally athymic rats and control (rnu/+) thymic heterozygous rats have been studied. Serum IgM, and serum and salivary IgA levels were virtually identical between rnu/rnu and rnu/+ rats. Serum IgG was drastically reduced in nude rats during the period when endogenous IgG synthesis was predominant. The most consistent and pronounced differences in Ig levels between rnu/rnu and rnu/+ rats involved the IgG isotype.
摘要
对先天性无胸腺裸鼠（rnu/rnu）和对照胸腺杂合鼠（rnu/+）血清及唾液中的免疫球蛋白（Ig）水平进行了研究。rnu/rnu鼠与rnu/+鼠的血清IgM、血清及唾液IgA水平实际上是相同的。在内源性IgG合成占主导的时期，裸鼠的血清IgG大幅降低。rnu/rnu鼠与rnu/+鼠之间Ig水平最一致且显著的差异涉及IgG同种型。
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