Taubman M A, Ebersole J L, Smith D J
Immunology. 1986 May;58(1):145-9.
The levels of immunoglobulins (Ig) in the serum and saliva of nude (rnu/rnu), congenitally athymic rats and control (rnu/+) rats were studied after injection in the vicinity of the salivary glands with several different T-dependent or T-independent dinitrophenylated antigens. Serum IgG levels were higher in rnu/+ rats than rnu/rnu rats after both primary and secondary immunizations. WHile serum IgM levels were higher in rnu/+ rats after primary immunization, secondary immunization with the most thymic-dependent antigens elicited higher IgM levels in rnu/rnu rats. After primary immunization, serum IgA levels in rnu/rnu rats were significantly lower than rnu/+ levels but no differences between the groups were noted after secondary immunization. Primary immunization with these antigens also demonstrated a markedly reduced salivary IgA producing capability by the athymic rats. Importantly, no such differences in serum or salivary IgA were previously found in the absence of immunization. Thus, immunization accentuated differences in Ig level and isotype distribution between rnu/rnu and rnu/+ rats.
在用几种不同的T细胞依赖性或T细胞非依赖性二硝基苯基化抗原注射到唾液腺附近后，研究了无胸腺（rnu/rnu）先天性无胸腺大鼠和对照（rnu/+）大鼠血清和唾液中的免疫球蛋白（Ig）水平。在初次和二次免疫后，rnu/+大鼠的血清IgG水平均高于rnu/rnu大鼠。虽然初次免疫后rnu/+大鼠的血清IgM水平较高，但用最依赖胸腺的抗原进行二次免疫后，rnu/rnu大鼠的IgM水平更高。初次免疫后，rnu/rnu大鼠的血清IgA水平显著低于rnu/+大鼠，但二次免疫后两组之间未观察到差异。用这些抗原进行初次免疫也显示无胸腺大鼠的唾液IgA产生能力明显降低。重要的是，在未进行免疫的情况下，之前未发现血清或唾液IgA有此类差异。因此，免疫加剧了rnu/rnu和rnu/+大鼠之间Ig水平和同种型分布的差异。
