正常和病理性人体红细胞渗透阻力的测量。

Measurement of osmotic resistance of normal and pathological human red blood cells.

作者信息

Saxena R K, Seshadri V

出版信息

Indian J Physiol Pharmacol. 1983 Jan-Mar;27(1):1-6.

Abstract

The changes in the osmotic resistance of red blood cells (RBC), due to various pathological conditions like exposure to heat, anemia as well as the effect of storage and anticoagulants have been investigated. The results have shown that exposure to a temperature of 50 degrees C makes the red blood cells fragile to osmotic pressures. Also, red blood cells from the patients suffering from anemia exhibited decreased osmotic resistance. Storage upto 9 days showed a marginal increase in the osmotic fragility of the RBC and beyond that, there was no significant effect upto 15 days. Also, exposure to anticoagulants like citrate, ammonium oxalate, and EDTA increased the osmotic fragility of the cells. The present study shows that the various traumas investigated will affect the mechanical properties of the red blood cell membrane.

摘要

已经对由于暴露于热、贫血等各种病理状况以及储存和抗凝剂的影响而导致的红细胞（RBC）渗透抵抗力的变化进行了研究。结果表明，暴露于50摄氏度的温度会使红细胞对渗透压变得脆弱。此外，贫血患者的红细胞表现出渗透抵抗力下降。储存长达9天显示红细胞的渗透脆性略有增加，在此之后，直到15天没有显著影响。而且，暴露于柠檬酸盐、草酸铵和乙二胺四乙酸等抗凝剂会增加细胞的渗透脆性。本研究表明，所研究的各种损伤会影响红细胞膜的力学性能。