大鼠体内苯乙烯三种含硫尿代谢物的鉴定。
Identification of three sulphur-containing urinary metabolites of styrene in the rat.
作者信息
Seutter-Berlage F, Delbressine L P, Smeets F L, Ketelaars H C
出版信息
Xenobiotica. 1978 Jul;8(7):413-8. doi: 10.3109/00498257809070025.
PMID:685290
Abstract
- After administration of styrene (1) to rat, three sulphur-containing urinary metabolites were isolated in the molar ratio of III : IV : V equal to 65 : 34 : 1. 2. These metabolites were identified as N-acetyl-S-(1-phenyl-2-hydroxyethyl)cysteine (III), N-acetyl-S-(2-phenyl-2-hydroxyethyl)cysteine (IV) and N-acetyl-S-(phenacyl)cysteine (V). 3. After a single dose (250 mg/kg, 2.4 mmol/kg) styrene, the totally excreted mercapturic acids in the urine amounted to 10.7 +/- 1.0% (n = 5) of the dose.
摘要
- 将苯乙烯（1）给予大鼠后，分离出三种含硫的尿代谢物，其摩尔比为III:IV:V等于65:34:1。2. 这些代谢物被鉴定为N-乙酰基-S-(1-苯基-2-羟乙基)半胱氨酸（III）、N-乙酰基-S-(2-苯基-2-羟乙基)半胱氨酸（IV）和N-乙酰基-S-(苯甲酰甲基)半胱氨酸（V）。3. 单次给予苯乙烯剂量为250mg/kg（2.4mmol/kg）后，尿中总排泄的硫醇尿酸相当于给药剂量的10.7±1.0%（n = 5）。
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