Rousseau J, Autenrieth D, van Lier J E
Int J Appl Radiat Isot. 1983 Mar;34(3):571-9. doi: 10.1016/0020-708x(83)90058-3.
99Tc-labeled-tetrasulfophthalocyanine was prepared by the condensing of sulfophthalic acid and pertechnetate in the presence of a reducing agent. Reaction products were purified in various chromatographic systems and characterized by combustion, specific activity and spectral analyses. The tissue distribution pattern of the major product was studied in tumor-bearing rats. Most of the activity accumulated in the liver, kidneys, ovaries and uterus, whereas tumor uptake mainly occurred in the exterior cell layers. The in vivo stability of the complex was evidenced by the absence of 99Tc accumulation in the thyroid and the stomach.
99Tc标记的四磺酸酞菁是通过在还原剂存在下使磺酸酞酸与高锝酸盐缩合制备的。反应产物在各种色谱系统中进行纯化，并通过燃烧、比活度和光谱分析进行表征。在荷瘤大鼠中研究了主要产物的组织分布模式。大部分活性积聚在肝脏、肾脏、卵巢和子宫中，而肿瘤摄取主要发生在外层细胞层。复合物在体内的稳定性通过甲状腺和胃中不存在99Tc积聚得到证明。
