Friedman S J, Doyle J A
Int J Dermatol. 1983 Apr;22(3):171-6. doi: 10.1111/j.1365-4362.1983.tb03358.x.
The typical infection with Sporothrix schenckii is characterized by superficial cutaneous nodules occurring along the lines of lymphatic drainage of the limbs. Review of the medical records at the Mayo Clinic from 1937 to the present disclosed 58 patients with sporotrichosis. Eleven patients had evidence of extracutaneous infection. Eight of the patients were men whose ages ranged from 25 to 71 years; the ages of the three women were 54, 64, and 67. Seven patients had predominantly joint involvement, with the knee and wrist joints being most often infected. Other sites of infection included the mandible and ethmoid sinuses. Three patients had disseminated systemic infection, and one patient died within a year of the initial diagnosis. Nine patients had been in good health before the infection, although five patients were taking systemic corticosteroids before their infection was diagnosed. Therapies included supersaturated potassium iodide, amphotericin B, and 2-hydroxystilbamidine isethionate. Although most commonly seen as a cutaneous disease, sporotrichosis is a potentially disseminated infection with life-threatening consequences.
申克孢子丝菌的典型感染表现为沿肢体淋巴引流途径出现的浅表皮肤结节。回顾梅奥诊所1937年至今的病历，发现58例孢子丝菌病患者。11例有皮肤外感染的证据。其中8例为男性，年龄在25至71岁之间；3例女性的年龄分别为54岁、64岁和67岁。7例主要累及关节，膝关节和腕关节最常受累。其他感染部位包括下颌骨和筛窦。3例有播散性全身感染，1例在初诊后一年内死亡。9例患者在感染前身体健康，不过5例患者在感染被诊断前正在服用全身性皮质类固醇。治疗方法包括超饱和碘化钾、两性霉素B和羟乙磺酸二脒替。尽管孢子丝菌病最常见为一种皮肤疾病，但它是一种潜在的播散性感染，可导致危及生命的后果。
