Khanna A, Reddy T S
Int J Vitam Nutr Res. 1983;53(1):3-8.
Studies were made of the effects of undernutrition and Vitamin A deficiency on the phospholipid composition of liver, spleen and kidney in rat. Undernutrition and vitamin A deficiency cause a significant deficit in body and tissue weights. But the deficit seems to be more in undernourished rats. Significant deficits were found in the concentration of total phospholipid in livers from both the experimental groups. This decrease in total phospholipid was reflected in most of the phospholipids with a significant decrease in phosphatidyl serine and inositol fraction of undernourished rats. The concentration of total phospholipid in the spleen was increased in undernourished rats. This increase was mainly confined to the sphingomyelin fraction. However the phosphatidyl choline was found to decrease in undernourished rats. No major changes were observed in the concentration of different phospholipids of kidney from the experimental rats. These results suggest that undernutrition and vitamin A deficiency have differential effects on the phospholipid composition of different tissues and the effects of vitamin A deficiency seems to be due to general growth retardation rather than the specific effect of vitamin A per se.
对大鼠进行了关于营养不足和维生素A缺乏对肝脏、脾脏和肾脏磷脂组成影响的研究。营养不足和维生素A缺乏会导致体重和组织重量显著下降。但这种下降在营养不足的大鼠中似乎更为明显。在两个实验组大鼠的肝脏中，总磷脂浓度均显著降低。总磷脂的这种减少反映在大多数磷脂上，营养不足大鼠的磷脂酰丝氨酸和肌醇部分显著减少。营养不足大鼠脾脏中的总磷脂浓度增加。这种增加主要局限于鞘磷脂部分。然而，发现营养不足大鼠的磷脂酰胆碱减少。实验大鼠肾脏中不同磷脂的浓度未观察到重大变化。这些结果表明，营养不足和维生素A缺乏对不同组织的磷脂组成有不同影响，维生素A缺乏的影响似乎是由于普遍的生长迟缓，而非维生素A本身的特定作用。
