Ananth U S, Ramakrishnan C V, Hauser G
Lipids. 1986 Mar;21(3):226-9. doi: 10.1007/BF02534826.
The effects of undernutrition on polyphosphoinositide levels in rat kidneys removed and frozen immediately after animal death or 10 min later were determined. Weanling (21-day-old) rats of dams fed a 5 or 22% protein diet and litters fed either normal or protein-deficient diets for an additional six wk were used. Nutritional deprivation lowered phosphatidylinositol-4-phosphate (PtdIns4P) preferentially (35-40%) but preserved phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P2) at weaning. This effect was not completely reversed in animals nutritionally rehabilitated after weaning. Postweaning protein deficiency did not reduce the levels of these lipids. Postmortem loss was the same for all five groups, minimal for PtdIns4P and about one-third for PtdIns4,5P2.
测定了营养不足对动物死亡后立即摘除并冷冻或10分钟后摘除并冷冻的大鼠肾脏中多磷酸肌醇水平的影响。使用了由喂食5%或22%蛋白质饮食的母鼠哺育的断奶（21日龄）大鼠，以及另外六周喂食正常或蛋白质缺乏饮食的同窝幼崽。营养剥夺优先降低了磷脂酰肌醇-4-磷酸（PtdIns4P）（35%-至40%），但在断奶时保留了磷脂酰肌醇-4,5-二磷酸（PtdIns4,5P2）。这种影响在断奶后营养恢复的动物中并未完全逆转。断奶后蛋白质缺乏并未降低这些脂质的水平。所有五组的死后损失相同，PtdIns4P最小，PtdIns4,5P2约为三分之一。
