Ogawa Y, Imanaka K, Ashida C, Takashima H, Imajo Y, Kimura S
Int J Radiat Oncol Biol Phys. 1983 Apr;9(4):533-7. doi: 10.1016/0360-3016(83)90072-x.
Active specific immunotherapy using the immune reaction of a low-dose irradiated tumor tissue was studied on the transplanted MM46 tumor of female C3H/He mice after radiotherapy. MM46 tumor cells were inoculated into the right hind paws of mice. On the 5th day, irradiation with the dose of 3000 rad was performed. On the 11th day, tumor cells and mononuclear cells, which were separated from the low-dose irradiated tumor tissue (2000 rad on the fifth day), were injected into the left hind paws of the tumor-bearing mice. Effectiveness of this active specific immunotherapy against tumor was evaluated by the regression of tumor and survival rate of mice. Tumor was markedly regressed and survival rate was significantly increased by the active specific immunotherapy.
在放疗后对雌性C3H/He小鼠移植的MM46肿瘤进行了使用低剂量照射肿瘤组织免疫反应的主动特异性免疫治疗研究。将MM46肿瘤细胞接种到小鼠右后爪。第5天，进行3000拉德剂量的照射。第11天，将从低剂量照射肿瘤组织（第5天2000拉德）分离出的肿瘤细胞和单核细胞注射到荷瘤小鼠的左后爪。通过肿瘤消退和小鼠存活率评估这种主动特异性免疫治疗对肿瘤的有效性。主动特异性免疫治疗使肿瘤明显消退，存活率显著提高。
