Vasilescu I, Topciu V l, Fitărău A, Teodorescu R, Marţincu V, Moldovan E, Gavrilescu M
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1977 Jan-Mar;22(1):43-6.
Investigations were carried out concerning the dynamics of antivaccinal antibodies and the structure of serum proteins in relation to the clinical manifestations following upon smallpox vaccination. In general, immunity is not apparently influenced by postvaccinal complications may be associated with immunoprotein perturbations, manifested by an increase in the alpha2-globulin fraction and, inconstantly, in the gamma-globulin fraction. Immunoelectrophoretic determinations revealed a relatively constant IgM and IgG deficiency. Postvaccinal dysglobulinemia may accompany various clinical forms, suggesting a temporary deficient immunological response. In one case of agammaglobulinemia, revaccination produced a deep vaccinal ulcer, with extensive necrosis (giant necrotic vaccinia). In order to decipher the substrate of the reaction in the clinical forms with distal manifestations or generalized vaccinia, skin biopsies were performed. The lesional vasculoallergic substrate of the skin lesions does not exclude the local aggression of the vaccinal virus, which was isolated by viral determinations.
针对天花疫苗接种后的临床表现，对抗疫苗抗体动力学和血清蛋白结构进行了研究。一般来说，免疫功能显然不受疫苗接种后并发症的影响，这些并发症可能与免疫蛋白紊乱有关，表现为α2球蛋白部分增加，γ球蛋白部分偶尔增加。免疫电泳测定显示IgM和IgG相对持续缺乏。疫苗接种后球蛋白异常血症可能伴随各种临床症状，提示免疫反应暂时不足。在一例无丙种球蛋白血症患者中，再次接种导致深部疫苗溃疡，并伴有广泛坏死（巨大坏死性牛痘）。为了解析具有远端表现或全身性牛痘的临床症状中反应的底物，进行了皮肤活检。皮肤病变的损伤性血管过敏底物并不排除疫苗病毒的局部侵袭，病毒检测分离出了该病毒。
