Holter O, Bergan T, Flørenes T, Leinebø O
J Antimicrob Chemother. 1983 Apr;11(4):357-60. doi: 10.1093/jac/11.4.357.
One dose of 500 mg metronidazole (M) was given to 21 patients before appendectomy and the concentrations of the parent compound and the major metabolite hydroxymetronidazole (OH-M), assayed in serum and tissue homogenates of appendix and subcutaneous tissues by high pressure liquid chromatography. Based on determinations in one specimen per patient during the initial 1.25-4 h after end of the 50 min infusion, the levels of M in relation to serum were 60.8% (+/- S.D. 19.8) for the appendix and 29.0% +/- 8.7 for subcutaneous tissue. The corresponding values for OH-M were 103.9 +/- 28.2 and 57.0% +/- 16.8. The slope of the log-linear regression curves of M corresponded to elimination half-life (T 1/2) values of 5.2 h in serum, 2.7 h in appendix and 2.6 h in subcutis tissue, but the differences were not statistically significant. The values of OH-M were similar for serum and appendix. OH-M had T 1/2 of 7.9 and 6.1 h for serum and subcutaneous tissue and 21.3 h in the appendix, but the values were not significantly different.
在阑尾切除术前，给21例患者服用一剂500毫克甲硝唑（M），然后通过高压液相色谱法测定血清以及阑尾和皮下组织匀浆中母体化合物和主要代谢产物羟基甲硝唑（OH-M）的浓度。根据在50分钟输注结束后的最初1.25 - 4小时内对每位患者的一个样本进行的测定，与血清相比，阑尾中M的水平为60.8%（±标准差19.8），皮下组织中为29.0%±8.7。OH-M的相应值分别为103.9±28.2和57.0%±16.8。M的对数线性回归曲线斜率对应的血清消除半衰期（T 1/2）值为5.2小时，阑尾中为2.7小时，皮下组织中为2.6小时，但差异无统计学意义。血清和阑尾中OH-M的值相似。OH-M在血清和皮下组织中的T 1/2分别为7.9和6.1小时，在阑尾中为21.3小时，但这些值差异不显著。
