Gelberman R H, Szabo R M, Williamson R V, Dimick M P
J Bone Joint Surg Am. 1983 Jun;65(5):632-8.
Sensibility testing in peripheral-nerve compression syndromes was investigated in an experimental study in humans. Twelve volunteer subjects had controlled external compression of the median nerve at the carpal tunnel at a level of forty, fifty, sixty, and seventy millimeters of mercury. The subjects were then monitored for thirty to 240 minutes with four sensory tests: two-point discrimination, moving two-point discrimination, Semmes-Weinstein pressure monofilaments, and vibration. Sensory and motor conduction, subjective sensations, and motor strength were also continuously tested. The threshold tests (vibration and Semmes-Weinstein monofilaments testing) consistently reflected gradual decreases in nerve function in both subjective sensation and electrical testing, while the innervation density tests (two-point discrimination and moving two-point discrimination) remained normal until nearly all sensory conduction had ceased. Decreased muscle strength occurred late, and not until changes had already occurred in each of the sensory tests. Threshold tests of sensibility correlated accurately with symptoms of nerve compression and electrodiagnostic studies, and are being evaluated for clinical use in a variety of peripheral-nerve compression syndromes.
在一项人体实验研究中，对外周神经卡压综合征的感觉测试进行了调查。12名志愿者受试者的腕管处正中神经受到40、50、60和70毫米汞柱水平的控制性外部压迫。然后，通过四项感觉测试对受试者进行30至240分钟的监测：两点辨别、动态两点辨别、Semmes-Weinstein压力单丝测试和振动测试。还持续测试了感觉和运动传导、主观感觉以及运动强度。阈值测试（振动和Semmes-Weinstein单丝测试）在主观感觉和电测试中均持续反映出神经功能的逐渐下降，而神经支配密度测试（两点辨别和动态两点辨别）在几乎所有感觉传导停止之前仍保持正常。肌肉力量下降出现较晚，且直到每项感觉测试都已出现变化才会发生。感觉阈值测试与神经压迫症状和电诊断研究准确相关，目前正在对其在各种外周神经卡压综合征中的临床应用进行评估。
