异烟肼（INH）对瑞士小鼠的围产期致癌性。
Perinatal carcinogenicity of isoniazid (INH) in Swiss mice.
作者信息
Menon M M, Bhide S V
出版信息
J Cancer Res Clin Oncol. 1983;105(3):258-61. doi: 10.1007/BF00395754.
Abstract
Tumorigenicity of isoniazid (INH) and hydrazine sulfate (HS) was studied in male and virgin Swiss mice. The INH and HS induced 50% und 84% lung tumors in males and 67% and 72% in females, respectively. Both chemicals induced lung tumors in animals of the F1 generation that were exposed to INH or HS during intrauterine life, lactation, and in the postweaning period. Surprisingly, the F2 generation from these F1 animals, which were exposed to INH only during gestation and lactation, showed earlier and much higher tumor incidence than the parent generation.
摘要
在雄性和未交配的瑞士小鼠中研究了异烟肼（INH）和硫酸肼（HS）的致瘤性。INH和HS分别在雄性小鼠中诱导出50%和84%的肺部肿瘤，在雌性小鼠中分别诱导出67%和72%的肺部肿瘤。这两种化学物质在子宫内生活、哺乳期和断奶后接触过INH或HS的F1代动物中都诱发了肺部肿瘤。令人惊讶的是，这些仅在妊娠和哺乳期接触过INH的F1代动物的F2代，其肿瘤发生率比亲代更早且更高。
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本文引用的文献
1
Uterine vascular clamping: new procedure for the study of congenital malformations.
Science. 1960 Jul 8;132(3419):89-91. doi: 10.1126/science.132.3419.89-a.
2
Transplacental, biological & metabolic effects of isoniazid (INH) in Swiss mice.异烟肼（INH）对瑞士小鼠的经胎盘、生物学及代谢影响
Indian J Exp Biol. 1980 Oct;18(10):1104-6.
3
Transplacental passage of isoniazid (INH) and its interaction with fetal tissues of mice.异烟肼（INH）的胎盘转运及其与小鼠胎儿组织的相互作用。
Biochem Pharmacol. 1983 Feb 15;32(4):617-9. doi: 10.1016/0006-2952(83)90484-7.
4
Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats.对怀孕大鼠单次注射乙基亚硝基脲后子代的致畸和致癌作用。
Nature. 1966 Jun 25;210(5043):1378-9. doi: 10.1038/2101378a0.
5
Vaginal cancer after maternal treatment with synthetic estrogens.母亲接受合成雌激素治疗后发生的阴道癌。
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6
Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women.阴道腺癌。年轻女性母亲接受己烯雌酚治疗与肿瘤出现的关联。
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7
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Proc Soc Exp Biol Med. 1970 Oct;135(1):84-6. doi: 10.3181/00379727-135-34993.
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10
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J Natl Cancer Inst. 1971 Sep;47(3):645-51.
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