用于分析未衍生化药物的熔融石英柱技术进展。
Advances in fused-silica column technology for the analysis of underivatized drugs.
作者信息
Plotczyk L L, Larson P
出版信息
J Chromatogr. 1983 Mar 4;257(2):211-26. doi: 10.1016/s0021-9673(01)88177-2.
The chemical durability of a cross-linked 5% phenyl methylsilicone stationary phase is investigated for the analysis of underivatized drugs. Column performance is tested with respect to quantitative reproducibility, solvent extractability, selectivity for various drug families, and capacity for the polar solute. Data are presented showing the effects of a polar solvent and a serum extract on column lifetime with splitless and cool on-column injection. Examples of a human drug screen and the forensic analysis of street heroin are provided.
研究了交联5%苯基甲基硅氧烷固定相用于未衍生化药物分析时的化学耐久性。针对定量重现性、溶剂萃取性、对各种药物家族的选择性以及对极性溶质的容量对柱性能进行了测试。给出的数据显示了极性溶剂和血清提取物对不分流进样和冷柱头进样时柱寿命的影响。提供了人体药物筛查和街头海洛因法医分析的示例。
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