Aznar J, Santos M T, Valles J, Sala J
J Clin Pathol. 1983 Jun;36(6):712-5. doi: 10.1136/jcp.36.6.712.
Serum malondialdehyde-like material (MDA-LM), as an index of lipid peroxidation, and the serum enzymes CK, CK-MB, LDH, LDH1 and, alpha-HBDH were evaluated in a group of 26 patients with acute myocardial infarction (AMI), seven with angina pectoris (AP), and in a normal control group of 94 subjects. MDA-LM values were within the normal range in AP patients, while in AMI patients a significant increase in serum MDA-LM was observed in the days following the acute event, reaching a maximum 6-8 days later, when 90% of the patients had values higher than the upper normal limit (mean +/- 2SD) of the control group. A significant correlation was found between the integrated concentration-time MDA-LM curve and the integrated serum enzymes activity curves reached during the nine days after the acute event. The "in vivo" relevance of the increased serum MDA-LM in the post-infarct period is unknown at the present, but as lipid peroxides are known to harm cellular structures and to inhibit prostacyclin synthesis, it may be of interest with regard to the long term secondary effects in AMI patients.
作为脂质过氧化指标的血清类丙二醛物质（MDA-LM）以及血清酶肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）、乳酸脱氢酶1（LDH1）和α-羟丁酸脱氢酶（α-HBDH）在一组26例急性心肌梗死（AMI）患者、7例心绞痛（AP）患者以及94名正常对照者中进行了评估。AP患者的MDA-LM值在正常范围内，而在AMI患者中，急性事件后的数天内血清MDA-LM显著升高，在6 - 8天后达到峰值，此时90%的患者的值高于对照组的正常上限（均值±2标准差）。在急性事件后的九天内，MDA-LM的综合浓度-时间曲线与血清酶活性综合曲线之间存在显著相关性。目前尚不清楚梗死后期血清MDA-LM升高在“体内”的相关性，但由于已知脂质过氧化物会损害细胞结构并抑制前列环素合成，这可能与AMI患者的长期继发效应有关。
