Spellman G G, Gruebel B J, Epstein J D, Rotman H H, Weg J G
J Clin Pharmacol. 1983 Feb-Mar;23(2-3):82-8. doi: 10.1002/j.1552-4604.1983.tb02708.x.
The bronchodilator effect of fenoterol hydrobromide (0.5, 1.25, and 2.5 mg) was compared with either isoproterenol (2.8 mg) or isoetharine (5 mg) with phenylephrine (1.25 mg) in a double-blind placebo-controlled study. When delivered by an intermittent positive-pressure breathing device to 24 nonsmoking young adult asthmatic subjects, fenoterol produced significant improvement in forced expiratory volume at 1 second (FEV1), in maximum midexpiratory flow (FEF25-75%), and in forced expiratory flow at 25 per cent of vital capacity (FEF25%) for 6 to 8 hours, whereas isoproterenol and isoetharine with phenylephrine produced improvement for 1 and 2 hours, respectively. The lowest dosage of fenoterol was as effective as the highest but had fewer adverse effects.
在一项双盲安慰剂对照研究中，将氢溴酸非诺特罗（0.5、1.25和2.5毫克）的支气管扩张作用与异丙肾上腺素（2.8毫克）或异他林（5毫克）加去氧肾上腺素（1.25毫克）进行了比较。当通过间歇正压呼吸装置给予24名不吸烟的年轻成年哮喘患者时，非诺特罗使第1秒用力呼气量（FEV1）、最大呼气中期流速（FEF25-75%）和肺活量25%时的用力呼气流量（FEF25%）在6至8小时内有显著改善，而异丙肾上腺素和异他林加去氧肾上腺素分别在1小时和2小时内产生改善。非诺特罗的最低剂量与最高剂量效果相同，但不良反应较少。
