Newman L J, Richards W, Church J A
Ann Allergy. 1982 Apr;48(4):230-2.
Eighteen children in status asthmaticus, six to 14 years of age, were systematically studied to compare the efficacy of aerosolized isoetharine and isoproterenol. The studies were conducted in a randomized, double-blind fashion. Five inhalations of 1% isoetharine and 0.5% isoproterenol were administered via a wall-mounted air/O2 nebulizing unit. Pulse, respiratory rate, blood pressure, FVC, PEFR, FEV1 and FEF25-75 were measured at the patient's bedside. Isoetharine produced significantly less cardiac side effect and tended to produce a greater improvement in pulmonary function than did isoproterenol. In addition, no change from baseline was noted in any of the parameters at 120 minutes following treatment with either medication.
对18名年龄在6至14岁的哮喘持续状态儿童进行了系统研究，以比较雾化异丙喘宁和异丙肾上腺素的疗效。研究采用随机、双盲方式进行。通过壁挂式空气/氧气雾化器给予1%异丙喘宁和0.5%异丙肾上腺素各5次吸入。在患者床边测量脉搏、呼吸频率、血压、用力肺活量（FVC）、呼气峰流速（PEFR）、第一秒用力呼气容积（FEV1）和25%-75%用力呼气流量（FEF25-75）。与异丙肾上腺素相比，异丙喘宁产生的心脏副作用明显较少，且在肺功能改善方面往往更显著。此外，两种药物治疗后120分钟，任何参数均未出现与基线相比的变化。
