Cooper T W, Santa Cruz D J, Bauer E A
J Am Acad Dermatol. 1983 Apr;8(4):463-7. doi: 10.1016/s0190-9622(83)70050-2.
Verruciform xanthoma is a rare, granular, plaque-like lesion which occurs on mucosal surfaces and is characterized by acanthosis with xanthoma cells in the dermis between rete pegs. A case of verruciform xanthoma is reported which occurred on the sacral region in a patient with recessive dystrophic epidermolysis bullosa (RDEB). Electron microscopic studies suggested that many of the xanthoma cells were fibroblasts whose vacuolated appearance was expressed in cell culture and persisted for several passages. The occurrence of a verruciform xanthoma in a patient with severe recessive dystrophic epidermolysis bullosa suggests that repeated epidermal and/or dermal damage gave rise to a reactive process involving the formation of lipid-laden cells.
疣状黄色瘤是一种罕见的、颗粒状、斑块样病变，发生于黏膜表面，其特征为棘层肥厚，真皮乳头间有黄色瘤细胞。本文报道1例发生于隐性营养不良型大疱性表皮松解症（RDEB）患者骶部的疣状黄色瘤。电子显微镜研究显示，许多黄色瘤细胞为成纤维细胞，其空泡状外观在细胞培养中出现，并持续传代数代。严重隐性营养不良型大疱性表皮松解症患者发生疣状黄色瘤提示，反复的表皮和/或真皮损伤引发了一个涉及形成富含脂质细胞的反应过程。
