Katzenstein A L, Sale S R, Greenberger P A
J Allergy Clin Immunol. 1983 Jul;72(1):89-93. doi: 10.1016/0091-6749(83)90057-x.
The clinical and pathologic features of seven cases of a newly recognized form of chronic sinusitis are described. Most patients were young adults with a history of asthma, and all had chronic nasal polyps. Radiographically, there was opacification of multiple sinuses. Recurrent sinusitis was common, and several patients underwent numerous surgical drainage procedures. Histologically, a distinct mucinous material containing eosinophils, Charcot-Leyden crystals, and fungal hyphae was found in tissue resected from the sinuses. We believe that these findings constitute a distinct clinicopathologic entity that we term allergic Aspergillus sinusitis. This condition shares similar histopathologic features with allergic bronchopulmonary aspergillosis (ABPA) but affects the paranasal sinuses rather than the lung. Implications for therapy of this form of sinusitis and its possible relationship to allergic lung diseases are discussed.
本文描述了7例新发现的慢性鼻窦炎的临床和病理特征。大多数患者为有哮喘病史的年轻成年人，且均患有慢性鼻息肉。影像学检查显示多个鼻窦混浊。复发性鼻窦炎很常见，数名患者接受了多次手术引流。组织学检查发现，从鼻窦切除的组织中有一种独特的黏液物质，其中含有嗜酸性粒细胞、夏科-莱登晶体和真菌菌丝。我们认为这些发现构成了一种独特的临床病理实体，我们将其称为变应性曲霉菌性鼻窦炎。这种疾病与变应性支气管肺曲霉菌病（ABPA）具有相似的组织病理学特征，但累及鼻窦而非肺部。本文还讨论了这种鼻窦炎的治疗意义及其与变应性肺部疾病可能的关系。
