Morikawa F
Nihon Sanka Fujinka Gakkai Zasshi. 1983 Apr;35(4):517-26.
To find the cause of insulin resistance in pregnancy, the effects of estradiol (0.002 mg/day) treatment in male (n = 6) and ovariectomized (n = 8) rats, progesterone (0.05 mg/day) treatment in male (n = 9) and female (n = 6) and ovariectomized (n = 8) rats and combined estradiol and progesterone treatment in male (n = 7) and ovariectomized (n = 8) rats on (1-14C) glucose oxidation and insulin receptors in isolated fat cells were examined. All groups were treated for 5 days. Control rats were treated with the solvents. The results were as follows: 1) Decreased responsiveness to insulin on (1-14C) glucose oxidation was observed in adipocytes from male rats treated with estradiol and estradiol + progesterone, female rats treated with progesterone and ovariectomized rats treated with estradiol + progesterone. 2) There was no significant difference among the insulin bindings to adipocytes from rats treated with estradiol, progesterone and estradiol + progesterone. These results suggest that estradiol itself is potent in inducing insulin resistance in male rats, but in female rats progesterone primed with estradiol is necessary to induce insulin resistance, and that they may act at some post-receptor sites. These sex hormones may play an important role in inducing the insulin resistance in pregnancy.
为探究妊娠期间胰岛素抵抗的原因，研究了雌二醇（0.002毫克/天）对雄性（n = 6）和去卵巢（n = 8）大鼠的作用、孕酮（0.05毫克/天）对雄性（n = 9）、雌性（n = 6）和去卵巢（n = 8）大鼠的作用以及雌二醇与孕酮联合使用对雄性（n = 7）和去卵巢（n = 8）大鼠的作用，观察其对分离脂肪细胞中（1-14C）葡萄糖氧化及胰岛素受体的影响。所有组均接受5天治疗。对照大鼠接受溶剂处理。结果如下：1）在用雌二醇、雌二醇 + 孕酮处理的雄性大鼠、用孕酮处理的雌性大鼠以及用雌二醇 + 孕酮处理的去卵巢大鼠的脂肪细胞中，观察到对胰岛素的（1-14C）葡萄糖氧化反应性降低。2）在用雌二醇、孕酮和雌二醇 + 孕酮处理的大鼠的脂肪细胞中，胰岛素结合情况无显著差异。这些结果表明，雌二醇本身可有效诱导雄性大鼠产生胰岛素抵抗，但在雌性大鼠中，需要孕酮与雌二醇协同作用才能诱导胰岛素抵抗，且它们可能作用于某些受体后位点。这些性激素可能在妊娠期间诱导胰岛素抵抗中起重要作用。
