Chidi C C, King D R, Boles E T
J Pediatr Surg. 1983 Apr;18(2):109-15. doi: 10.1016/s0022-3468(83)80529-6.
In an experimental study, catheterization of the abdominal aorta with small umbilical artery catheters consistently produced significant intimal injury. The duration of catheterization varied from 1 hr to 7 days, and recovery periods following catheter removal varied from 1-150 days. Endothelial disruption was observed in all animals sacrificed within 24 hr of catheter removal. Healing progressed rapidly when the duration of catheterization was short, but was protracted with longer periods of catheterization. Thrombi were frequently found adhering to the exposed subendothelial surface. Routine light, scanning, and transmission electron microscopy demonstrated consistent cellular changes, which depended upon the duration of catheterization and the length of recovery periods. A consistent relationship between the degree of intimal injury and the duration of catheterization was observed.
在一项实验研究中，用小的脐动脉导管插入腹主动脉持续造成显著的内膜损伤。导管插入的持续时间从1小时到7天不等，拔除导管后的恢复期从1天到150天不等。在拔除导管后24小时内处死的所有动物中均观察到内皮破坏。当导管插入持续时间短时，愈合进展迅速，但随着导管插入时间延长而延迟。经常发现血栓附着于暴露的内皮下表面。常规光学显微镜、扫描电子显微镜和透射电子显微镜显示出一致的细胞变化，这些变化取决于导管插入的持续时间和恢复期的长短。观察到内膜损伤程度与导管插入持续时间之间存在一致的关系。
