Ito T, Horisawa M, Ando H
J Pediatr Surg. 1983 Apr;18(2):124-30. doi: 10.1016/s0022-3468(83)80532-6.
Intrahepatic bile ducts were investigated by operative cholangiography in 6 patients with the correctable type of biliary atresia, by percutaneous transhepatic cholangiography in 5 patients with noncorrectable type and by electron microscopy in biopsied hepatic tissues in 17 patients. Intrahepatic bile ducts were pathologic even in the early stage of the disease and they were involved all the way from bile ductules to large main hepatic ducts. The correlation between the prognosis and the electron microscopic presence of lumenal obstruction suggests that the pathologic change of intrahepatic bile ducts is one of the main factors determining prognosis.
对6例可矫正型胆道闭锁患者通过术中胆管造影检查肝内胆管，对5例不可矫正型患者通过经皮经肝胆管造影检查，对17例患者通过活检肝组织的电子显微镜检查肝内胆管。即使在疾病早期，肝内胆管也有病理改变，从胆小管到肝主大管均受累。管腔阻塞的电子显微镜表现与预后之间的相关性表明，肝内胆管的病理改变是决定预后的主要因素之一。
