Hill D T, Stanley K G, Williams J E, Loev B, Fowler P J, McCafferty J P, Macko E, Berkoff C E, Ladd C B
J Med Chem. 1983 Jun;26(6):865-9. doi: 10.1021/jm00360a015.
A series of substituted 1,3-diaryltriazenes has been synthesized and tested for anorectic activity. Several members of the series were effective; one compound, 1,3-bis[2-cyano-5-(trifluoromethyl)phenyl]triazene, was particularly active, causing weight loss in rats, dogs, and squirrel monkeys. It was devoid of overt central nervous system activity, and compared to previously reported biologically active triazenes, it was relatively nontoxic up to 30 days of drug administration.
已合成了一系列取代的1,3 - 二芳基三氮烯，并对其厌食活性进行了测试。该系列中的几个成员具有活性；一种化合物，1,3 - 双[2 - 氰基 - 5 -（三氟甲基）苯基]三氮烯特别活跃，能使大鼠、狗和松鼠猴体重减轻。它没有明显的中枢神经系统活性，并且与先前报道的具有生物活性的三氮烯相比，在给药30天内相对无毒。
