吗啡和哌替啶对冠状动脉阻力、血压及心肌梗死所致心律失常的影响。

Effects of morphine and pethidine on coronary vascular resistance, blood pressure, and myocardial infarction-induced cardiac arrhythmias.

作者信息

Pant K K, Verma V K, Mishra N, Singh N, Sinha J N, Bhargava K P

出版信息

Jpn Heart J. 1983 Jan;24(1):127-33. doi: 10.1536/ihj.24.127.

DOI:10.1536/ihj.24.127

Abstract

In the present study, the effects of morphine and pethidine on coronary vessel resistance (CPP), blood pressure (BP), and experimental myocardial infarction-induced cardiac arrhythmia were investigated. Both morphine and pethidine induced a fall in CPP and BP and inhibited the cardiac arrhythmia. The morphine effects on CPP and BP were largely blocked by mepyramine. The effects of pethidine, on the other hand, were not blocked by mepyramine, propranolol, or atropine. An interesting dose dependent inhibition of cardiac arrhythmia was observed with pethidine.

摘要

在本研究中，研究了吗啡和哌替啶对冠状动脉阻力（CPP）、血压（BP）以及实验性心肌梗死诱发的心律失常的影响。吗啡和哌替啶均导致CPP和BP下降，并抑制心律失常。吗啡对CPP和BP的作用在很大程度上被美吡拉敏阻断。另一方面，哌替啶的作用未被美吡拉敏、普萘洛尔或阿托品阻断。观察到哌替啶对心律失常有有趣的剂量依赖性抑制作用。