Togo S, Shimoda T, Hachiya K, Yuno S, Takahashi H, Ujiie H, Watanabe S, Kondo O, Kashimura K, Hosoya T, Ogoshi H, Yanagita S, Tachihara Y, Suzuki N, Sakurai K
Gan No Rinsho. 1983 Apr;29(4):A-24, 369-74.
A 22-year-old male who had been receiving insulin therapy to treat uncontrollable hyperglycemia, was diagnosed to have a carcinoid in the lower rectum. The excised tumor was 1.5 cm in diameter, and showed a yellowish-white cut surface. It did not invade into the proper muscle. Numerous glucagon immunoreactive cells were found. The tumor cells contained many rounded neurosecretory granules. After tumor excision, the patient's hyperglycemia did not return in the absence of insulin administration. We suggest that the tumor may have secreted glucagon which may have acted as an antagonist against insulin in the circulation.
一名22岁男性，因难以控制的高血糖一直接受胰岛素治疗，被诊断为低位直肠类癌。切除的肿瘤直径为1.5厘米，切面呈黄白色。未侵犯固有肌层。发现大量胰高血糖素免疫反应性细胞。肿瘤细胞含有许多圆形神经分泌颗粒。肿瘤切除后，患者在未使用胰岛素的情况下高血糖未复发。我们认为该肿瘤可能分泌了胰高血糖素，其在循环中可能起到了胰岛素拮抗剂的作用。
