Aminoadipic acid toxic effects on retinal glial cells.

The toxic effects of DL-alpha-aminoadipic acid on retinal glial cells were examined histologically following intravitreal injection to rats or rabbits. There was a marked swelling Müller cells, astrocytes and oligodendrocytes, but no changes in the microglia. Injections of a low concentration of the solution (0.1 mg in 0.01 ml) produced no irreversible damage to the Müller cells. With high concentrations (1 mg in 0.01 ml), there was a necrosis of Müller cells followed by thinning of the retina and disruption of the outer limiting membrane,