用于视网膜修复的细胞移植策略。
Cell transplantation strategies for retinal repair.
作者信息
West E L, Pearson R A, MacLaren R E, Sowden J C, Ali R R
机构信息
Department of Genetics, UCL Institute of Ophthalmology, London, UK.
出版信息
Prog Brain Res. 2009;175:3-21. doi: 10.1016/S0079-6123(09)17501-5.
Abstract
Cell transplantation is a novel therapeutic strategy to restore visual responses to the degenerate adult neural retina and represents an exciting area of regenerative neurotherapy. So far, it has been shown that transplanted postmitotic photoreceptor precursors are able to functionally integrate into the adult mouse neural retina. In this review, we discuss the differentiation of photoreceptor cells from both adult and embryonic-derived stem cells and their potential for retinal cell transplantation. We also discuss the strategies used to overcome barriers present in the degenerate neural retina and improve retinal cell integration. Finally, we consider the future translation of retinal cell therapy as a therapeutic strategy to treat retinal degeneration.
摘要
细胞移植是一种恢复退化的成年神经视网膜视觉反应的新型治疗策略，代表了再生神经治疗中一个令人兴奋的领域。到目前为止，已经表明移植的有丝分裂后光感受器前体细胞能够在功能上整合到成年小鼠神经视网膜中。在这篇综述中，我们讨论了来自成年和胚胎干细胞的光感受器细胞的分化及其在视网膜细胞移植中的潜力。我们还讨论了用于克服退化神经视网膜中存在的障碍并改善视网膜细胞整合的策略。最后，我们考虑视网膜细胞治疗作为治疗视网膜变性的治疗策略的未来转化。
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本文引用的文献
1
Generation of retinal cells from mouse and human induced pluripotent stem cells.从小鼠和人类诱导多能干细胞生成视网膜细胞。
Neurosci Lett. 2009 Jul 24;458(3):126-31. doi: 10.1016/j.neulet.2009.04.035. Epub 2009 Apr 18.
2
Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells.先前被鉴定为视网膜干细胞的细胞是色素性睫状上皮细胞。
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6685-90. doi: 10.1073/pnas.0901596106. Epub 2009 Apr 3.
3
Neural progenitor potential in cultured Müller glia: effects of passaging and exogenous growth factor exposure.培养的 Müller 胶质细胞的神经祖细胞潜能：传代及外源性生长因子暴露的影响
Brain Res. 2008 Sep 16;1230:1-12. doi: 10.1016/j.brainres.2008.03.095. Epub 2008 Jul 8.
4
Sialoadhesin expression in intact degenerating retinas and following transplantation.完整退变视网膜及移植后唾液酸黏附素的表达
Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5602-10. doi: 10.1167/iovs.08-2117. Epub 2008 Jul 18.
5
Progenitor cell-derived factors enhance photoreceptor survival in rat retinal explants.祖细胞衍生因子可增强大鼠视网膜外植体中光感受器的存活能力。
Brain Res. 2008 Aug 28;1227:226-33. doi: 10.1016/j.brainres.2008.06.077. Epub 2008 Jun 28.
6
Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors.通过双因子重编程从成年神经干细胞诱导产生的多能干细胞。
Nature. 2008 Jul 31;454(7204):646-50. doi: 10.1038/nature07061. Epub 2008 Jun 29.
7
Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium.通过植入视网膜及视网膜色素上皮改善视网膜变性患者的视力。
Am J Ophthalmol. 2008 Aug;146(2):172-182. doi: 10.1016/j.ajo.2008.04.009. Epub 2008 Jun 10.
8
Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina.从成年Chx10(orJ/orJ) 中枢神经视网膜中分离并鉴定神经祖细胞。
Mol Cell Neurosci. 2008 Jul;38(3):359-73. doi: 10.1016/j.mcn.2008.03.008. Epub 2008 Apr 10.
9
Effect of gene therapy on visual function in Leber's congenital amaurosis.基因治疗对莱伯先天性黑蒙视觉功能的影响。
N Engl J Med. 2008 May 22;358(21):2231-9. doi: 10.1056/NEJMoa0802268. Epub 2008 Apr 27.
10
Safety and efficacy of gene transfer for Leber's congenital amaurosis.基因转移治疗莱伯先天性黑蒙的安全性和有效性。
N Engl J Med. 2008 May 22;358(21):2240-8. doi: 10.1056/NEJMoa0802315. Epub 2008 Apr 27.
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