West E L, Pearson R A, MacLaren R E, Sowden J C, Ali R R
Department of Genetics, UCL Institute of Ophthalmology, London, UK.
Prog Brain Res. 2009;175:3-21. doi: 10.1016/S0079-6123(09)17501-5.
Cell transplantation is a novel therapeutic strategy to restore visual responses to the degenerate adult neural retina and represents an exciting area of regenerative neurotherapy. So far, it has been shown that transplanted postmitotic photoreceptor precursors are able to functionally integrate into the adult mouse neural retina. In this review, we discuss the differentiation of photoreceptor cells from both adult and embryonic-derived stem cells and their potential for retinal cell transplantation. We also discuss the strategies used to overcome barriers present in the degenerate neural retina and improve retinal cell integration. Finally, we consider the future translation of retinal cell therapy as a therapeutic strategy to treat retinal degeneration.
细胞移植是一种恢复退化的成年神经视网膜视觉反应的新型治疗策略，代表了再生神经治疗中一个令人兴奋的领域。到目前为止，已经表明移植的有丝分裂后光感受器前体细胞能够在功能上整合到成年小鼠神经视网膜中。在这篇综述中，我们讨论了来自成年和胚胎干细胞的光感受器细胞的分化及其在视网膜细胞移植中的潜力。我们还讨论了用于克服退化神经视网膜中存在的障碍并改善视网膜细胞整合的策略。最后，我们考虑视网膜细胞治疗作为治疗视网膜变性的治疗策略的未来转化。
