Lopukhin Iu M, Klimov A N, Archokov A I, Sergienko V I, Nagornev V A
Kardiologiia. 1983 Mar;23(3):11-4.
Hemosorption is a method of rapid control of hypercholesterolemia. A study of hemocompatibility of an alumosilicate sorbent which is relatively selective with respect to cholesterol demonstrated a possibility of its being used in hemosorption devices. Rabbits with spontaneous regression of two-month duration were given three hemosorption sessions. A drop in cholesterol and triglycerides was noted after each session. By the end of the experiment, the area of aortal atherosclerotic lesion was reduced twofold as compared to the controls (19% vs. 41%). Rapid regression of diffuse lipid deposits from the surface and marginal zones of the patches was observed. "New" secondary lipid deposits were absent. A possibility of using hemosorption in patients with pronounced hypercholesterolemia is discussed.
血液吸附是一种快速控制高胆固醇血症的方法。一项关于对胆固醇具有相对选择性的硅铝酸盐吸附剂血液相容性的研究表明，其可用于血液吸附装置。对持续两个月自然消退的兔子进行了三次血液吸附治疗。每次治疗后均观察到胆固醇和甘油三酯水平下降。实验结束时，与对照组相比，主动脉粥样硬化病变面积减少了一半（19%对41%）。观察到斑块表面和边缘区域的弥漫性脂质沉积迅速消退。未见“新的”继发性脂质沉积。文中讨论了在明显高胆固醇血症患者中使用血液吸附的可能性。
