[Role of collateral coronary circulation in the compensation of regional disorders of energy metabolism in the myocardium in experimental myocardial ischemia].

Patterns of glucose, pyruvate and lactate consumption by the ischemized myocardium were studied in dog experiments with reference to the leve of retrograde inflow to the network of the ligated coronary artery. For this purpose, blood samples were taken from distal portion of ligated anterior descending coronary artery and the great cardiac vein accompanying the branches of the former. The increase of the lactate level, "excessive" lactate, the redox potential of the lactate/pyruvate system (E), delta E was shown to be less pronounced in those experiments where collateral coronary flow volumetric rate was above 1.5 ml/min, whereas pH and pO2 values dropped more steeply following coronary ligation in the experiments with small retrograde inflow to the ischemized area. The differences between glucose and pyruvate consumption by the ischemized myocardium were not significant.