Akaike A, Sasa M, Takaori S
Life Sci. 1983 Jun 6;32(23):2649-53. doi: 10.1016/0024-3205(83)90356-9.
Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc neurons was clearly antagonized by simultaneous application of haloperidol, and a partial antagonism by sulpiride was observed in 3 out of 10 Acc neurons. These results indicate that dopamine produces an inhibition of the Acc neuron and that, compared to haloperidol, sulpiride is a less potent blocker of the postsynaptic dopamine receptor involved in the dopamine-induced inhibition.
采用微离子透入法进行研究，以阐明水合氯醛麻醉大鼠伏隔核（Acc）中的多巴胺能机制。在45个接受测试的伏隔核神经元中，通过离子透入法施加多巴胺可抑制28个（62%）由谷氨酸诱导的放电。同时施加氟哌啶醇可明显拮抗多巴胺对14个伏隔核神经元的抑制作用，在10个伏隔核神经元中有3个观察到舒必利有部分拮抗作用。这些结果表明，多巴胺可抑制伏隔核神经元，与氟哌啶醇相比，舒必利是参与多巴胺诱导抑制作用的突触后多巴胺受体的较弱阻断剂。
