Thompson C I, Zagon I S
Neurobehav Toxicol Teratol. 1983 Jan-Feb;5(1):17-21.
Offspring of female rats injected daily with dl-methadone hydrochloride (5 mg/kg, IP) or saline were cross-fostered at birth to form drug groups exposed throughout gestation only, or both gestation and lactation; controls were exposed only to saline. At approximately 80 days, 120 offspring (20 from each drug group and 60 controls, sexes equally represented) were adapted to a 23-hr water deprivation schedule and individually trained to obtain water in a test cage containing a single water spout. Each methadone-exposed rat then competed with a control animal for access to the water during two 5-min sessions. Under competitive conditions, methadone-exposed rats spent less time at the water spout than did the controls (p less than 0.02); this effect occurred in males and females from all three drug group, and was unrelated to body weight. These results suggest that social dominance may be reduced in the offspring of mother rats given methadone.
每天腹腔注射盐酸消旋美沙酮（5毫克/千克）或生理盐水的雌性大鼠所产的后代，在出生时进行交叉寄养，以形成仅在整个妊娠期、或在妊娠期和哺乳期均接触药物的组；对照组仅接触生理盐水。在大约80日龄时，120只后代（每个药物组20只，60只对照组，雌雄各半）适应23小时禁水方案，并在含有单个饮水口的测试笼中单独训练获取水。然后，每只接触美沙酮的大鼠在两个5分钟的时间段内与一只对照动物竞争获取水的机会。在竞争条件下，接触美沙酮的大鼠在饮水口停留的时间比对照组少（p小于0.02）；这种效应在所有三个药物组的雄性和雌性中均出现，且与体重无关。这些结果表明，给予美沙酮的母鼠后代的社会优势可能会降低。
