Kikuchi S, Matsumoto H, Ito M
Neurochem Res. 1983 Mar;8(3):313-8. doi: 10.1007/BF00965721.
The levels of free amino acids in the cerebral cortex of acute and chronic uremic rats were examined. Amino acids significantly elevated were aspartate, glutamine, glycine, histidine, ornithine, phenylalanine, phosphoethanolamine and taurine, whereas 1-methyl histidine and 3-methyl histidine were specifically detected in uremic rats. Glutamate, arginine and carnosine disclosed a significant reduction. There was no change in the concentrations of gamma-aminobutyrate and alanine. The above findings were essentially identical in both acute and chronic uremia. It was conjectured that these changes of amino acid levels in the brain might participate in the progress of uremic encephalopathy.
检测了急性和慢性尿毒症大鼠大脑皮层中游离氨基酸的水平。显著升高的氨基酸有天冬氨酸、谷氨酰胺、甘氨酸、组氨酸、鸟氨酸、苯丙氨酸、磷酸乙醇胺和牛磺酸，而在尿毒症大鼠中特异性检测到了1-甲基组氨酸和3-甲基组氨酸。谷氨酸、精氨酸和肌肽显著减少。γ-氨基丁酸和丙氨酸的浓度没有变化。上述结果在急性和慢性尿毒症中基本相同。据推测，大脑中氨基酸水平的这些变化可能参与了尿毒症性脑病的进展。
