Linderkamp O, Wu P Y, Meiselman H J
Pediatr Res. 1983 Apr;17(4):250-3. doi: 10.1203/00006450-198304000-00003.
Red blood cell (RBC) geometry is a determinant of RBC deformability, survival time, osmotic resistance, and oxygen uptake. Because accurate information on the geometry of neonatal RBC appears lacking, a micropipette technique was employed to measure surface area and volume of individual neonatal and adult RBC. In addition, RBC diameter was determined microscopically. From these measurements, surface area index (actual surface area divided by area of sphere of same volume), swelling index (maximal volume divided by actual volume), minimum cylindrical diameter and mean thickness of RBC were calculated. Compared to adult cells, the volume of neonatal RBC was 21% larger, their surface area was 13% greater and their diameter 11% wider. The surface area-to-volume ratio of the neonatal RBC was 1.42 +/- 0.08 and that of the adult RBC was 1.49 +/- 0.06 (P less than 0.05). The minimum cylindrical diameter of the neonatal RBC was 3.04 +/- 0.25 microns and that of the adult RBC was 2.81 +/- 0.23 microns (P less than 0.05). Mean RBC thickness, surface area index and swelling index were not significantly different.
红细胞（RBC）的几何形状是决定红细胞变形性、存活时间、渗透压耐受性和氧摄取的一个因素。由于似乎缺乏关于新生儿红细胞几何形状的准确信息，因此采用微量移液器技术来测量单个新生儿和成人红细胞的表面积和体积。此外，通过显微镜确定红细胞直径。根据这些测量结果，计算出表面积指数（实际表面积除以相同体积球体的面积）、肿胀指数（最大体积除以实际体积）、红细胞的最小圆柱直径和平均厚度。与成人细胞相比，新生儿红细胞的体积大21%，表面积大13%，直径宽11%。新生儿红细胞的表面积与体积之比为1.42±0.08，成人红细胞为1.49±0.06（P<0.05）。新生儿红细胞的最小圆柱直径为3.04±0.25微米，成人红细胞为2.81±0.23微米（P<0.05）。红细胞平均厚度、表面积指数和肿胀指数无显著差异。
