Anastassiades O T, Spiliades C, Tsakraklides E, Gogas J
Pathol Res Pract. 1983 Mar;176(2-4):200-15. doi: 10.1016/S0344-0338(83)80011-9.
The study is based on 112 consecutive mastectomy specimens with carcinoma. Breasts were grossly divided into three basic types: solid, when showing a sizable cone of solid tissue (mammary tissue and fibrous stroma), fatty when almost completely replaced by fat, and intermediary types Ia and Ib. It appears that these types represent stages of an evolutionary process involving the anatomical structure of the breast during life. Mammary alterations gradually lead to lobular atrophy. Generalized lobular atrophy characterizes mainly fatty breasts. Lesions of fibrocystic disease are frequent in breasts of all types. In all three types of breast carcinomas were more frequently located in the outer portion of the breast. Rare locations of carcinomas are associated with the type of breast: a central location is more frequent in fatty, an inner location in intermediary and a diffuse in solid breasts. In fatty breasts irregular tumors are common while in solid breasts tumors without clear borders appear to develop. Multicentric carcinomas were much more frequent in solid breasts than in the other types of breasts. Most multicentric carcinomas are accompanied by multicentric carcinoma in situ. Infiltrative lobular and mixed (lobular-ductal) carcinomas are accompanied by lobular carcinoma in situ, lobular cancerization or both. In infiltrative ductal and the special types of carcinomas the histology of carcinoma in situ differs according to whether or not the infiltrative tumor is single or multicentric. The difference concerns the complete lack of lobular cancerization from cases with single infiltrative tumors.
该研究基于112例连续的乳腺癌乳房切除术标本。乳房在大体上分为三种基本类型：实性，表现为有相当大的实性组织（乳腺组织和纤维基质）圆锥体；脂肪性，几乎完全被脂肪替代；以及中间类型Ia和Ib。似乎这些类型代表了一生中涉及乳房解剖结构的进化过程的各个阶段。乳腺改变逐渐导致小叶萎缩。全身性小叶萎缩主要是脂肪性乳房的特征。纤维囊性疾病的病变在所有类型的乳房中都很常见。在所有这三种类型中，乳腺癌更常位于乳房的外侧部分。癌的罕见位置与乳房类型有关：脂肪性乳房中癌位于中央更为常见，中间类型乳房中癌位于内侧更为常见，实性乳房中癌呈弥漫性更为常见。在脂肪性乳房中，不规则肿瘤很常见，而在实性乳房中，似乎会出现边界不清的肿瘤。实性乳房中的多中心癌比其他类型的乳房更为常见。大多数多中心癌伴有多中心原位癌。浸润性小叶癌和混合性（小叶 - 导管性）癌伴有小叶原位癌、小叶癌化或两者皆有。在浸润性导管癌和特殊类型的癌中，原位癌的组织学根据浸润性肿瘤是单中心还是多中心而有所不同。这种差异涉及单中心浸润性肿瘤病例中完全没有小叶癌化。
