Charocopos F
Q J Exp Physiol. 1983 Apr;68(2):153-9. doi: 10.1113/expphysiol.1983.sp002707.
The integrity of renal haemodynamics is essential for the maintenance of normal renal function in the normotensive and hypertensive state. Systemic and renal haemodynamics have been determined by the radioactively labelled microspheres technique in normotensive, Goldblatt I, Goldblatt II and deoxycorticosterone (DOC)-saline-treated hypertensive rats. Cardiac output was similar between normotensive and hypertensive rats, while total peripheral resistance was similarly higher in all hypertensive animals when compared to normotensive animals. Renal blood flow per weight unit was similarly decreased in all hypertensive animals (3.77 ml/min . g (S.D. 0.85, n = 11); the unclipped kidneys of Goldblatt II rats, 3.76 ml/min . g (S.D. 0.89, n = 11); the clipped kidneys of Goldblatt II rats, 3.62 ml/min . g (S.D. 0.78, n = 9); the kidneys of Goldblatt I rats and 2.95 ml/min . g (S.D. 0.83, n = 10) the kidneys of DOC-saline rats). It is concluded that kidneys from experimentally hypertensive rats fail to preserve normal renal blood flow, even at elevated arterial blood pressures, regardless of the pathophysiology of hypertension.
肾血流动力学的完整性对于维持正常血压和高血压状态下的正常肾功能至关重要。已采用放射性标记微球技术测定了正常血压大鼠、Goldblatt I型高血压大鼠、Goldblatt II型高血压大鼠和脱氧皮质酮（DOC）-盐水处理的高血压大鼠的全身和肾血流动力学。正常血压大鼠和高血压大鼠的心输出量相似，而与正常血压动物相比，所有高血压动物的总外周阻力同样更高。所有高血压动物每单位重量的肾血流量均有相似程度的降低（3.77毫升/分钟·克（标准差0.85，n = 11）；Goldblatt II型大鼠未夹闭的肾脏，3.76毫升/分钟·克（标准差0.89，n = 11）；Goldblatt II型大鼠夹闭的肾脏，3.62毫升/分钟·克（标准差0.78，n = 9）；Goldblatt I型大鼠的肾脏以及2.95毫升/分钟·克（标准差0.83，n = 10）DOC-盐水大鼠的肾脏）。得出的结论是，实验性高血压大鼠的肾脏即使在动脉血压升高时也无法维持正常的肾血流量，无论高血压的病理生理学机制如何。
