Lloyd R D, Bruenger F W, Jones C W, Taylor G N, Mays C W
Radiat Res. 1983 Apr;94(1):210-6.
Retention of 226Ra was substantially lower in mature beagles injected at 5 years of age compared to corresponding values for young adult beagles injected at 17 months of age. As with young adults, the percentage retention in mature dogs given about 10 microCi/kg exceeded that in mature dogs given 4 microCi/kg or less. Percentage retention, R, at t days after the injection of 10 microCi/kg in mature beagles could be represented by the equation, R = 64.1e-0.233t + 13.0e-0.0048lt + 22.9e-0.000329t, and for mature beagles given 4 microCi/kg or less, R = 38.8e-0.40t + 30.6e-0.0424t + 11.9e-0.00567t + 18.7e-0.000352t. Measured 222Rn/226Ra ratios in bone were similar in mature and young adults. Roughly 66% of the injected radium was excreted by mature dogs during the first 3 weeks, about two-thirds of the total excretion appearing in the feces. Distribution of 226Ra within the skeleton was similar in mature and young adult beagles.
与17个月大的年轻成年比格犬注射后的相应值相比，5岁时注射的成年比格犬对226Ra的保留率要低得多。与年轻成年犬一样，给予约10微居里/千克的成年犬的保留百分比超过给予4微居里/千克或更低剂量的成年犬。成年比格犬注射10微居里/千克后t天的保留百分比R可用方程R = 64.1e-0.233t + 13.0e-0.00481t + 22.9e-0.000329t表示，而对于给予4微居里/千克或更低剂量的成年比格犬，R = 38.8e-0.40t + 30.6e-0.0424t + 11.9e-0.00567t + 18.7e-0.000352t。成年和年轻成年犬骨骼中测得的222Rn/226Ra比值相似。大约66%的注射镭在最初3周内由成年犬排出，约三分之二的总排泄物出现在粪便中。成年和年轻成年比格犬骨骼内226Ra的分布相似。
