Biphasic hypotensive effects of 5-methylfurmethide on the mean arterial blood pressure of rats.

The effects of 5-methylfurfuryltrimethylammonium iodide (5-methylfurmethide) on the mean arterial blood pressure of male Sprague-Dawley rats were investigated. The agent elicited a linear biphasic but non-parallel fall in the mean arterial blood pressure. The hypotensive effects were blocked by pretreatment of the animals with atropine suggesting the possible involvement of muscarinic receptors in the effects.