长期用阿托品治疗的大鼠对毒蕈碱的反应增强。
Enhanced responses to muscarine in rats treated chronically with atropine.
作者信息
Herman Z S, Słomińska-Zurek J
出版信息
Pol J Pharmacol Pharm. 1981;33(5):481-4.
PMID:7335552
Abstract
Rats were treated for 14 or 30 days with 10 mg/kg sc atropine (AT) daily. 24 h after the last dose of At, 50 micrograms of muscarine (MU) was injected intracerebroventricularly (ivtr.). Long-term atropinization enhanced the behavior induced by MU. These data support our previous suggestion that chronic blockade of central muscarinic receptors induces their hypersensitivity.
摘要
大鼠每日皮下注射10mg/kg阿托品（AT），持续14天或30天。在最后一剂阿托品给药24小时后，向脑室内注射50微克毒蕈碱（MU）。长期使用阿托品增强了毒蕈碱诱导的行为。这些数据支持了我们之前的观点，即中枢毒蕈碱受体的慢性阻断会诱导其超敏反应。
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